Rogala Lab

Publications

blue & bold — Rogala Lab member
Ψ — equal contribution
@ — corresponding author

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2

Martin S. TaylorΨ, Maggie ChenΨ, Matthew HancockΨ, Maximilian WranikΨ, Bryant D. Miller, Timothy R. O’Meara, Brad A. Palanski, Scott B. Ficarro, Brian J. Groendyke, Yufei Xiang, Kazuma T. Kondo, Karen Y. Linde-Garelli, Michelle J. Lee, Dibyendu Mondal, Daniel Freund, Samantha Congreve, Kaay Matas, Maximiliaan Hennink, Kera Xibinaku, Max L. Valenstein, Trevor van Eeuwen, Jarrod A. Marto, Andrej Sali, Yi Shi, Nathanael S. Gray, David M. Sabatini, Nam Chu@, Kacper B. Rogala@, and Philip A. Cole@.

Science. https://doi.org/10.1126/science.adv7111. 2026 March 5.

Structural basis for the dynamic regulation of mTORC1 by amino acids

Max L. ValensteinΨ, Maximilian WranikΨ, Pranav V. Lalgudi, Karen Y. Linde-Garelli, Yuri Choi, Raghu R. Chivukula, David M. Sabatini@, Kacper B. Rogala@.

Nature. https://doi.org/10.1038/s41586-025-09428-7. 2025 August 20.

Structures, functions, and adaptations of the human LINE-1 ORF2 protein

Eric T BaldwinΨ, Trevor van EeuwenΨ, David HoyosΨ, Arthur ZalevskyΨ, Egor P TchesnokovΨ, Roberto SánchezΨ, Bryant D MillerΨ, Luciano H Di StefanoΨ, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S TaylorΨ.

Nature. 2023 December 14.

Structural mechanisms of the mTOR pathway

Karen Y Linde-Garelli, Kacper B Rogala@.

Current Opinion in Structural Biology. 83(102663). 2023 August 10.

Structure of the nutrient-sensing hub GATOR2

Max L ValensteinΨ@, Kacper B RogalaΨ@, Pranav V. Lalgudi, Edward J Brignole, Xin Gu, Robert A Saxton, Lynne Chantranupong, Jonas Kolibius, Jan-Philipp Quast, David M Sabatini.

Nature. 607(7919):610-616. 2022 July 13.

Cryo-EM Structure of the Human FLCN-FNIP2-Rag-Ragulator Complex.

Kuang ShenΨ, Kacper B RogalaΨ, Hui-Ting Chou, Rick K Huang, Zhiheng Yu, David M Sabatini

Cell. 179(6):1319-1329.e8. 2019 November 27.

Structural basis for the docking of mTORC1 on the lysosomal surface.

Kacper B Rogala, Xin Gu, Jibril F Kedir, Monther Abu-Remaileh, Laura F Bianchi, Alexia M S Bottino, Rikke Dueholm, Anna Niehaus, Daan Overwijn, Ange-Célia Priso Fils, Sherry X Zhou, Daniel Leary, Nouf N Laqtom, Edward J Brignole, David M Sabatini.

Science. 366(6464):468-475. 2019 October 25.

Architecture of human Rag GTPase heterodimers and their complex with mTORC1.

Madhanagopal Anandapadamanaban, Glenn R Masson, Olga Perisic, Alex Berndt, Jonathan Kaufman, Chris M Johnson, Balaji Santhanam,
Kacper B Rogala, David M Sabatini, Roger L Williams.

Science. 366(6462):203-210. 2019 October 11.

Interaction between the Caenorhabditis elegans centriolar protein SAS-5 and microtubules facilitates organelle assembly.

Sarah BianchiΨ, Kacper B RogalaΨ, Nicola J DynesΨ, Manuel Hilbert, Sebastian A Leidel, Michel O Steinmetz, Pierre Gönczy, Ioannis Vakonakis.

Molecular Biology of the Cell. 29(6):722-735. 2018 March 15.

Cross-linking mass spectrometry identifies new interfaces of Augmin required to localise the γ-tubulin ring complex to the mitotic spindle.

Jack W C Chen, Zhuo A Chen, Kacper B Rogala, Jeremy Metz, Charlotte M Deane, Juri Rappsilber, James G Wakefield.

Biology Open. 6(5):654-663. 2017 May 15.